Tuesday, October 15, 2019

Capitalism versus Socialism Essay Example for Free

Capitalism versus Socialism Essay Budget deficit is just one of the many factors that negatively affect the provision of most of the government projects in the society. Without the sufficient amount of government funds, building of infrastructures and other public goods would be delayed or underprovided. As we can remember, there are some goods and services that can only be provided efficiently if the government is the one who supply it instead of the private firms to protect the rights and welfare of the consumer group. If there exist under provision of these public goods, the societal welfare would negatively be affected. In this regard, there is a question on whether what should prevail in our economy, capitalism or socialism? One may say that this debate between capitalism and socialism is already a cliche, but we cannot set aside the arguments and points of each side which could give us guide us in understanding what is happening in the real world. Let me discuss first capitalism. Capitalism promotes the concentration of the government in the provision of security in the society and not to intervene in the business world. Some capitalists say that, with the intervention of the government, person who wants to establish a business enterprise is being deprived due to the policies that are being implemented by the government. For instance, legal monopoly that was given by the government to some companies hinders other people from starting their own water/electric company. This failure of other people to start their own utility business, as capitalists believe, is a violation to their freedom. Socialism, on the other hand, is extremely the opposite of the capitalists thinking. Here, government intervention is very much welcome and the society is recognizing the ability of the government to efficiently handle companies and to equally distribute whatever the goods or service that they produce to their citizens. One good example to this is the provision of government of medical services and education. Since not all individuals can afford the costs of schooling provided by private firms, what the government does is they establish public schools charging at a minimum amount. As for the medical services, the government establishes public hospitals and clinics that would provide its citizens cheaper medical services and medicines for less capable people. With this, the basic right of human, to have education and access to medical services, is being fulfilled by the government. The reason why government provides efficient goods and services is due to the fact that they are providing the said goods and services at a reasonable price unlike private firms, especially monopolists, that charges above what is socially acceptable price. Now, based from the points of these two ideologies, therefore, it depends on the situation if whether a certain government intervention is good to the society. If the government interferes in the market in order to protect the welfare of its citizens, then, there is no room for capitalists to say that they are being deprived by the government to put their own business. In addition to that, establishing another utility business, like electric company, would be very costly due to the high fixed costs that they must face. This is the reason why it would be efficient if only one would continue ‘monopolize’ the production of electricity in the country. In this regard, if there would be an under provision of public goods like education, electricity, medical services and security due to budget deficit of the government; societal welfare would surely be greatly devastated. More people would be deprived with their basic human rights and might suffer to private firm’s abusing power. Only during instances wherein the private firms abuses their power and charge high to their customer by providing inelastic goods the government initiate actions to regulate the situation. Good Economics versus Good Politics One could say that an act promotes good economics if it aims for the maximization of the satisfaction of the society or market (Sharma, 2007). On the other hand, one could say that an act promotes good politics if it is backed up by a good policy for the welfare of the majority. Most of the analysts say that good economics leads to good politics and vice versa. Others believe that it’s the other way around. The point of the latter is that, making policies that promotes the no personal interest would lead to good economics since promoting the interest of the majority is tantamount to saying that they are maximizing the satisfaction of the society or they are after for the optimal level of societal welfare (Gittins, 2004). In order for each of the said ideals to exists, it must ensure the survival of one another. It seems hard for the politicians to set aside their personal political interest for the public interest but it should be done in order to attain what is really best for the economy and for the country. One way to promote the public interest is to lessen the burdens being imposed to the public like- tax (Gruen, 2007). Minimizing the tax rate would require a long battle and endless debate but the thing is, if all of the politicians would set aside their personal interest everything is possible for the government and they could act efficiently for the betterment of the economy. In this regard, there is no point arguing what is the best for the society- good economics or good politics, since one is needed for the existence of the other. Invisible Hand Principle Advocated by Adam Smith, invisible hand supports capitalist’s view. According to Adam Smith, the government must not intervene in the market and focus only on providing security and justice system to the society. They also believe that government lessens the societal welfare with their imposition of taxes. Taxes just add up to the operational costs of the businesses that in turn being passed to the consumers. In short, the burden of the taxes that are being imposed by the government goes to the end consumers. Adam Smith believes that market systems has its own mechanism to ‘heal’ itself and move back again towards the equilibrium condition even without the intervention of the government. By satisfying the ‘selfish’ motives of producers and consumers, they are unconsciously helping each other. Therefore, increasing the taxes rate collection of the government to cover the budget deficit would be an unwise idea since it would only add up to the burden of the consumers or the public. Government intervention must have the right timing and, as much as possible, impose less burden to the consumers. As what have been cited a while ago, government intervention depends on the situation and the condition between the private firms and the consumer group. Government intervention would only be sufficient if it uplifts the welfare of the consumer group with less negative effects on the private firms. But as for the increasing tax rate scenario, it seems that, although unintentionally, the government negatively affects the welfare of the consumer group while leaving the private firms unharmed since they only pass the taxes to the consumers. In this case, it would be better if the government let the ‘invisible hand’ or the free market system to put back into order the economy. Production Possibilities Curve There are some instances wherein private firms are being restricted in passing the added costs of government intervention to their consumers. Like for instance, the imposition of tariff on importers, tariff is another income generating activities of the government aside from taxation. With the extra expenses of the importers on every unit of goods that they are importing to the country, they can now only afford to buy less of the said imported goods depending on their allotted budget. In this scenario, the business would be producing below its production possibilities curve or PPF. This means that with the existence of higher tariffs on imported goods needed by local industries, the companies could only buy fewer imported raw materials and, therefore, producing fewer number of finished products than with the optimal level of production. This situation is treated to be inefficient, but since tariff is a form of income generation of the government, the only thing that the government could do is to find the efficient level of tariff rate wherein businesses could still produce closely to their PPF. With this, the value of the efficiency that is lost from the private firms would be justified and would return to them in a form of infrastructures in a form of roads and bridges which could alleviate the efficiency of their operation. In reality, it is pretty hard to produce within the PPF due to the existence of various intervening variables and tariff is one of them. The least thing that businesses could do is to produce closer to their PPF or their optimal level of production based on their capacity and capability. Opportunity Costs With the possibility of under provision of important government services, the government cannot afford to make it happen due to the high opportunity costs involved in the case. The government might forego the value of the welfare of its citizens in exchange of the improvement of the welfare of the corporations. If the welfare of the corporations and consumer group is to be calculated, the welfare of the consumer group is surely larger than with the welfare of the corporations in the market; and in the first place, it is the duty of the government to protect and prioritize the safety and welfare of the majority- citizens of their country. Just imagine the number of students that might stop schooling with the cutting of the budget for education; the number of sick and less capable citizens that only relies on the help of the government for cheaper medical services and/or medicines from public hospitals and clinics. To make the situation worst, the government prioritizes the welfare of Iraqis than with its own citizen. It was aired in the news that the government raised the amount of budget for the ‘peace keeping role’ of the government to Iraqi people. It is not bad to help other people, but ‘think first about the welfare of your own people before the others’ since that is the right thing to do. The point here is that, the reason why the government suffers to budget deficit is due to their wrong priorities. The government must not set aside the welfare of its citizen since it would bail them higher opportunity costs.

Monday, October 14, 2019

Brain Swelling in Pediatric Cerebral Malaria

Brain Swelling in Pediatric Cerebral Malaria 1.5T MRI to Investigate Potential Etiologies of Brain Swelling in Pediatric Cerebral Malaria Abbreviations: Red Blood Cell (RBC) Parts per billion (ppb) Cerebral malaria (CM) Blood brain barrier (BBB) Abstract Objective: Cerebral malaria (CM) remains a common cause of death in African children. The pathologic hallmark of pediatric CM is sequestration of parasitized red blood cells in the cerebral microvasculature. Recent Malawi-based research utilizing a 0.35T MRI has established that severe brain swelling is associated with fatal CM, but the etiology of brain swelling remains unclear. Autopsy and clinical studies suggest several potential etiologies, but technical limitations of 0.35T MRI precluded optimal investigations into swelling pathophysiology. A 1.5T MRI in Zambia allowed for further investigations including susceptibility weighted imaging (SWI). SWI is an ideal sequence for identifying regions of sequestration and microhemorrhages given the ferromagnetic properties of hemozoin and blood. Methods: Using 1.5T MRI, Zambian children with retinopathy-confirmed CM underwent imaging with SWI, T2, T1 pre- and post-gadolinium, DWI with ADC and T2/FLAIR sequences. Results: Sixteen children including two with moderate/severe edema were imaged. All survived. Gadolinium extravasation was not seen. Cerebral perfusion was intact with DWI abnormalities sparing the gray matter. SWI findings consistent with microhemorrhages and parasite sequestration co-occurred in white matter regions where DWI changes consistent with vascular congestion were seen. Findings consistent with posterior reversible encephalopathy syndrome as a cause of swelling were also present. Interpretations: High field MRI findings indicate that vascular congestion associated with parasite sequestration, local inflammation from microhemorrhages and autoregulatory dysfunction contribute to brain swelling in CM. Keywords: sequestration; venous congestion; hemozoin Introduction: Pediatric cerebral malaria (CM), defined as P. falciparum peripheral parasitemia and unarousable coma with no other coma etiology evident, primarily affects children in sub-Saharan Africa [1]. Although antimalarial agents provide rapid parasite clearance, mortality rates remain high (8-25%) [2, 3]. The pathological hallmark of pediatric CM at autopsy is intravascular sequestration in which parasitized red blood cells (RBCs) adhere to the endothelium of cerebral microvessels. Although malaria causes almost a million deaths per year, neuroimaging capacity is typically limited in malaria-endemic regions. Only one large MRI case series from Malawi using a 0.35T MRI has provided insights into the in vivo structural abnormalities associated with pediatric CM [4]and CM mortality [5]. Other studies and case reports using higher field MRIs have been performed on adults [6, 7], but adult CM appears to represent a different disease syndrome [8]. In adult CM, coma onset largely occurs some days after illness onset in the setting of multisystem organ failure often including hepatic dysfunction, renal failure and gross electrolyte abnormalities. As such, the coma of adult CM is clinically dominated by the effects of a toxic, metabolic encephalopathy. In contrast, in pediatric CM coma onset occurs very early in the malaria illness, often as one of the first signs of the illness, with very limited hepatic or renal involvement and no evident systemic cause for coma. MRI insights gained from imaging pediatric CM to date have been limited to low field MRI technology. The recent pediatric CM MRI study used 0.35T technology to establish that increased intracranial pressure due to increased brain volume is the cause of death in CM [9], but the low field MRI technology was unable to further evaluated the potential etiologies of brain swelling in pediatric CM, so the underlying cause(s) of cerebral edema in CM remains unclear. Further study delineating the underlying cause(s) of swelling is needed to develop appropriate interventions. Potential etiologies suggested by autopsy and clinical studies include any/all of the following: (a) blood brain barrier (BBB) breakdown with resultant vasogenic edema [10, 11]; (b) impaired perfusion resulting in cell death with cytotoxic edema [12]; (c) vascular congestion due to occlusion at the post-capillary venules [13]; (d) hyperemia with auto-regulatory dysfunction due to endothelial injury and CM-associated seizures, anemia and hyperpyrexia [14, 15], [16]; and (e) diffuse cerebral microhemorrhages (i.e. ring hem orrhages) [11]. Hemozoin is an iron-rich breakdown product of the parasites metabolism of hemoglobin [5]. Hemozoin is present primarily in mature, sequestered parasites. Thus, susceptibility weighted imaging (SWI) [17], which is extremely sensitive to the magnetic field inhomogeneity caused by ferromagnetic substances, is an ideal imaging sequence for identifying regions of parasite sequestration. SWI also offers the ability to identify small hemorrhages on the order of several  µg of blood per gram of tissue [18],[19]. We hypothesized that imaging retinopathy-confirmed pediatric CM with a 1.5T MRI including DWI, SWI and gadolinium enhanced sequences would identify pathophysiological mechanisms underlying cerebral edema in pediatric CM and undertook an imaging study of CM in Zambia where 1.5T MRI is available specifically seeking evidence of blood brain barrier breakdown, impaired perfusion, parasite sequestration, autoregulatory dysfunction and microhemorrhages. Material and Methods: Subjects and Recruitment During the malaria seasons (Jan-June) in 2012-2014, comatose children with retinopathy-confirmed [20] CM underwent brain MRI on the 1.5T MRI scanner (Siemens Magnetom Essenza using Syngo MR 200 4A version software, Germany) at the Cancer Diseases Hospital in Lusaka, Zambia within 24 hours of admission. Inclusion criteria were: (1) admission to the pediatric high care unit of the University Teaching Hospital, (2) a Blantyre Coma Score of à ¢Ã¢â‚¬ °Ã‚ ¤ 2 [21], (3) P. falciparum infection as determined by a Paracheck Rapid Diagnostic Test (RDT), (4) the presence of malarial retinopathy, and (5) no other evident etiology for coma. A thick peripheral blood smear to identify parasitemia was also obtained prior to recruitment, but was not immediately available and was not required for inclusion. All children received standard antimalarial treatment, anticonvulsants, antipyretics, antibiotics and blood transfusions, as clinically indicated and in accordance with national treatment guidelin es. As per present treatment standards, no steroids were given. Children with comorbid meningitis as determined by cerebrospinal fluid analysis were excluded from enrollment. Written consent was obtained from the childs parent or guardian. Children with impaired renal function (creatinine à ¢Ã¢â‚¬ °Ã‚ ¥2.0) did not receive gadolinium. This study was approved by the Institutional Review Boards at the University of Zambia, Michigan State University and the University of Rochester. Imaging Gadolinium (Magnevist) doses were determined by individual patient weight and administered intravenously (0.2 mL/kg, 0.1 mmol/kg) by hand injection. The scanning protocol is provided in an appendix. Apparent diffusion coefficient (ADC) calculations were provided by the standard Siemens software algorithms [22]. SWI phase images were collected unfiltered and post-processed with a 6464 high pass filter then viewed using SPIN (signal processing in nMR) software. SWI was also collected with a shorter echo time (15ms) for some subjects to avoid potential aliasing [17]. Interpretation Images were reviewed independently by two radiologists (MJP; neuroradiologist, and SDK; MRI fellowship trained radiologist) and data were managed using NeuroInterp, a web-based program that allows radiographic findings to be entered into a searchable and quantified database [23]. Reader discrepancies, determined in advance of the analysis, were reevaluated by the two radiologists to develop a consensus interpretation. Increased brain volume, the imaging finding associated with fatal cerebral malaria, was rated on a scale from 1-8 with 3 being no edema, 1 and 2 indicating atrophy. An edema score of 4-5 indicated minimal-mild edema, with no loss of sulcal markings. Grade 6 (moderate edema) was defined as loss of some sulcal markings. An edema score of 7 represented moderate/severe edema with diffuse sulcal and cisternal effacement universally evident but without herniation present, and the severe edema score of 8 required sulcal and cisternal effacement with evidence of herniation. MRI findings coded within the NeuroInterp database that could plausibly be associated with the five potential pathogenic mechanisms of brain swelling in CM were then reviewed. Specifically, (a) to evaluate diffuse BBB breakdown causing vasogenic edema, we looked for evidence of gadolinium enhancement [24], (b) to assess for impaired perfusion and subsequent cytotoxic edema we looked for gray matter diffusion weighted imaging (DWI) abnormalities [25], (c) evidence for vascular congestion or venous micro-occlusion was sought by looking for white matter DWI abnormalities [26], (d) autoregulatory dysfunction was evaluated by looking for focal regions of symmetric hemispheric edema of varying confluence in regions susceptible to autoregulatory vulnerabilities [9, 27], and (e) SWI abnormalities were assessed clinically and quantitatively based upon effective voxel susceptibility with the anticipation that these would be located in the same anatomical regions as ring hemorrhages and sequest ration have been identified in prior autopsy studies [28]. Given the small anticipated sample size ( Results: Patient Characteristics and Data Acquisition Twenty three children met study inclusion criteria during the enrollment period. Parents declined participation for 2 children and 5 children were deemed too ill to transfer for imaging or died before imaging could be performed, so 16 subjects were imaged5 (31%) were male and the mean age was 6.4 years (range 1-15). Table 1 provides demographic data and admission clinical characteristics from the 16 subjects who were imaged. Of the 5 consented children who were not imaged, 3 died. Among the 16 subjects imaged, the scans for one patient was non-diagnostic on the SWI sequence due to movement artifact. Renal function could not be ascertained on two children, so these subjects did not receive gadolinium. There were no fatalities among the imaged study subjects and none had clinical sequelae evident at discharge. Table 2 provides the frequencies of the 1.5T MRI findings identified and captured in NeuroInterp. MRI Findings Increased brain volume: None of the subjects had severe (grade 8) edema. Moderate/severe (grade 7) edema was present in 2/16 (13%); moderate (grade 6) edema in 4/16 (25%); minimal/mild (grade 4 5) edema in 7/16 (44%) and no edema in 3/16 (19%). T2 signal changes: The total number of cases exhibiting white matter increased T2 signal was 12/16 (75%), and two distinct patterns were observed: primarily subcortical (10/12, or 83%) and primarily periventricular/peritrigoneal (2/12, 17%) (Figure 1). These generally occurred in isolation; only 2 cases had both findings. Gadolinium enhancement: The expected normal physiological intravascular and circumventricular organ enhancement was evident in all subjects on the post-contrast images (Figure 2). A small region of subtle focal cortical enhancement was seen in one subject with positive SWI signal and no associated T2 abnormalities consistent with a capillary telangiectasia. There was no evidence of gadolinium extravasation in the other 13 patients who received contrast. Cortical findings: Cortical swelling and increased T2 signal was seen in 10/16 (63%), but these signal abnormalities were relatively mild in extent, confluent, and without associated cortical DWI findings. Increased cortical T2 signal was generally diffuse, with only 2/16 (13%) having a posterior predominant pattern [4]. DWI showed restricted water diffusion in the subcortical white matter in 10/16 (63%) which was confirmed by accompanying ADC maps. Basal Ganglia and Thalamus Abnormalities: The structures in the basal ganglia had different levels of involvement. T2/FLAIR signal abnormalities were present in the globus pallidus and putamen in 10/16 (63%), and the caudate in 9/16 (56%). While frequently involved simultaneously, there was generally a region of predominance (Figure 3). Regional differences were also illustrated in the DWI images. Fifty six percent of subjects had DWI abnormalities in the globus pallidus, 13% in the putamen and none in the caudate. Pontine and Brainstem Signal Abnormalities: This was assessed at two levels, within the pons at the level of the middle cerebellar peduncle and within the brainstem at the level of the substantia nigra. Pontine involvement was seen in 9/16 (56%) and brainstem in 11/16 (69%). Abnormalities were usually diffuse, and consisted of generalized increase in T2 signal. However, focal areas of involvement were also seen. Corpus callosum: Showed increased T2 signal and thickening in 10/16 (63%) with 6/10 having associated positive DWI findings as confirmed by ADC maps. The splenium was the primary site of involvement in 9/10 (90%) of cases. SWI Findings: Decreased signal is defined as a positive SWI finding as it localizes to areas of magnetic field inhomogeneity caused by the presence of a ferromagnetic substance (Figure 4). SWI findings were noted along the regions of the venules of both the superficial and deep venous systems corresponding to areas of parasite sequestration and ring hemorrhages. SWI resolution did not allow distinction between gray and white matter involvement in the cerebellum. One SWI dataset was not interpretable due to severe motion artifact. In the remaining cases, 7/15 (47%) showed abnormal paramagnetic signal within the following regions of the parenchyma: corpus callosum (7/15, 47%), sub-cortical white matter (6/15, 40%), cerebellum (5/15, 33%), lenticulae striate (5/15, 33%), and periventricular white matter (2/15, 13%). In two subjects, both the internal capsule and optic radiation had abnormal paramagnetic signal. The susceptibility of heavily infected red blood cells is ~1880 parts per billion (ppb) relative to water [18]. The effective voxel susceptibilities in the corpus callosum and junction of the cortical gray and white matter was 50 ppb relative to water in SWIM. As distributed within the voxel, this represents a 1/38th decrease in susceptibility. Given the voxel size of 0.5 x 0.5 x 2.0 mm3, this represents 1/78th  µL. Assuming the capillary volume is ~5% (or 1/20th of the pixel) [29], this indicates that ~half of the capillaries are filled with hemozoin. The combination of moderate to severe symmetrical cortical swelling (edema score of 6 or 7), with corresponding underlying subcortical white matter changes with associated DWI and ADC findings was evident in 4/16 (25%) of cases (Figure 5) with two of the four showing a predominantly posterior distribution. Table 3 summarizes the MRI findings seen using 1.5T in 16 Zambian children with CM in the context of the proposed mechanisms for brain swelling in CM and the 1.5T MRI findings anticipated for each mechanism. Discussion: MRI findings using a 0.35T MRI have shown that death from pediatric CM occurs due to increased brain volume [9] but low field MRI was unable to further delineate the etiology for the brain swelling. Interventions studies aimed at reducing or preventing cerebral edema in CM would ideally target the underlying mechanism of swelling. Existing clinical and autopsy data suggest at least five potential etiologies for brain swelling in CM. In this study, we describe what the MRI findings associated with each of these potential etiologies would be and then used 1.5T MRI in children with retinopathy-confirmed CM to identify the presence or absence of findings consistent with each of the five proposed etiologies. As such, the results of this study can be subdivided into evidence both for and against these specific potential origins of brain swelling in pediatric CM. Decreased SWI signal was evident on the brain MRIs of children with CM and furthermore these changes were seen in regions where autopsy studies have shown microhemorrhages (Figure 6) as well as in the regions where sequestration is common. Since the SWI signal effectively identifies blood and hemozoin, both sequestration and ring hemorrhages were likely identified. Marked T2/DWI abnormalities were evident in the subcortical brain regions most sensitive to venous outflow obstruction. If perfusion is obstructed in regions with SWI signal changes, then blood flow to the tissue would decrease by ~50% which is consistent with what is seen in an animal model of malaria where blood flow was found to be reduced to 53% +/- 12% [29]. In the setting of the sequestration-associated SWI abnormalities and intact large venous drainage systems (i.e. no venous thrombosis), the T2/DWI findings are strongly suggestive of a venous obstruction phenomenon in the capillary bed system. Much of what is known about pediatric cerebral malaria has been learned from autopsy studies, so it is reassuring to see that the distribution of microhemorrhages and parasite sequestration found in prior autopsy studies are very similar in distribution to the microhemorrhages and parasite sequestration identified in living children who survived CM. Vasogenic edema was demonstrated by increased T2 signal in the white matter. Cytotoxic edema has a similar appearance, but is accompanied by restricted water motion identified by increased DWI signal. Both were evident in this cohort, with cytotoxic being more common. This tended to be significant and diffuse. None of these children died and there were no clinical sequelae at discharge, suggesting that the process is reversible, and may represent early cytotoxic edema rather than tissue infarction. MRI findings of symmetrical cortical swelling with underlying white matter changes were seen, consistent with posterior reversible encephalopathy syndrome (PRES) and suggestive of autoregulatory dysfunction. Pediatric CM is congruent with many other clinical conditions associated with PRES. Specifically, pediatric CM generally involves a rapid neurologic deterioration, usually in the setting of seizure, followed by relativity prompt full recovery in most patients. Radiographically, brain swelling with underlying vasogenic edema associated with positive DWI findings is the hallmark of both CM and PRES [4, 16]. Autoregulatory dysfunction as a result of the primarily endothelial process associated with parasite sequestration in CM may result in vasoconstriction coupled with hypoperfusion causing vasogenic edema and associated brain swelling. This is the favored theory for the etiology of the radiographic findings seen in PRES [27]. We found no evidence of cortical cytotoxic edema and there was no radiographic evidence of gadolinium enhancement although gadolinium was clearly seen within the vessels and in circumventricular organs. Gadolinium, as a contrast agent, is chelated by a range of very small molecules (Magnevist 0.54kDa)[30]. These agents are all hydrophobic, so they do not cross the intact BBB. At autopsy in CM, areas of sequestration show fibrinogen (340kDa)[24] leakage and ring hemorrhages which require sufficient BBB breakdown to allow a deformable, non-parasitized blood cells (7  µM) to escape. The SWI imaging in this study identified ring hemorrhages so some BBB breakdown associated with their presence must have occurred, but if there was associated gadolinium extravasation, the quantity and concentration of gadolinium was insufficient to be visually evident on MRI. Gross BBB breakdown indicative of severe vasogenic edema was not evident in this small series of non-fatal pediatric CM. This study is limited by the small sample size, less severe disease spectrum, and lack of a comparison group. In Zambia, children felt to be at risk of imminent death were not imaged since transport for imaging there requires ambulance transportation to an adjacent facility. The small number of subjects prevented meaningful quantitative analyses despite the use of NeuroInterp. Although no a prior analyses were planned, we did conducted a post-hoc comparison to determine if the edema score or the presence of SWI, DWI, or focal cortical abnormalities was associated with age, coma duration prior to admission or the seizures prior to admission. No associations were found (all ps >0.05). The absence of subjects with severe brain swelling or fatal disease may have impacted our findings, as florid BBB breakdown might not occur to a significant degree in less severe CM. Normal MRIs on a similar aged comparison group were not available. In the Zambian setting, most imaging is obtained on adva nced disease with normal images being uncommon. Acquisition of imaging in an age-comparable group of healthy children was not feasible given the risk of sedation, particularly in this environment. Finally, more quantitative MRI analyses would have allowed more optimal assessments, but the power injections equipment required to obtain perfusion studies and/or dynamic contrast enhanced studies, which could detect contrast influx too small to be visually evident, is prohibitively expensive and was not available in this resource limited setting. Conclusions: Pediatric CM brain MRI findings in non-fatal cases using 1.5T technology suggest that vascular congestion, autoregulatory dysfunction, and microhemorrhages likely contribute to brain swelling pathogenesis. References [1] WHO, World Malaria Report, 2011. http://www.who.int/malaria/publications/world-malaria-report-2016/report/en/ [2] A.M. Dondorp, C.I. Fanello, I.C. Hendriksen, E. Gomes, A. Seni, K.D. Chhaganlal, K. Bojang, R. Olaosebikan, N. Anunobi, K. Maitland, E. Kivaya, T. Agbenyega, S.B. Nguah, J. Evans, S. Gesase, C. Kahabuka, G. Mtove, B. Nadjm, J. Deen, J. Mwanga-Amumpaire, M. Nansumba, C. Karema, N. Umulisa, A. 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Melville, D.C. Warhurst, J.O. Osisanya, Separation of malaria-infected erythrocytes from whole blood: use of a selective high-gradient magnetic separation technique, Lancet 2(8237) (1981) 70-1. [6] D.D. Rasalkar, B.K. Paunipagar, D. Sanghvi, B.D. Sonawane, P. Loniker, Magnetic resonance imaging in cerebral malaria: a report of four cases, The British journal of radiology 84(1000) (2011) 380-5. [7] S. Vyas, V. Gupta, A. Hondappanavar, V. Sakhuja, N. Bhardwaj, P. Singh, N. Khandelwal, Magnetic resonance imaging of cerebral malaria, The Journal of emergency medicine 42(5) (2012) e117-9. [8] R.J. Maude, F. Barkhof, M.U. Hassan, A. Ghose, A. Hossain, M. Abul Faiz, E. Choudhury, R. Rashid, A. Abu Sayeed, P. Charunwatthana, K. Plewes, H. Kingston, R.R. Maude, K. Silamut, N.P. Day, N.J. White, A.M. Dondorp, Magnetic resonance imaging of the brain in adults with severe falciparum malaria, Malaria journal 13 (2014) 177. [9] K.B. Seydel, S.D. Kampondeni, C. Valim, M.J. Potchen, D.A. Milner, F.W. Muwalo, G.L. Birbeck, W.G. Bradley, L.L. Fox, S.J. Glover, C.A. Hammond, R.S. Heyderman, C.A. Chilingulo, M.E. Molyneux, T.E. Taylor, Brain swelling and death in children with cerebral malaria, N Engl J Med 372(12) (2015) 1126-37. [10] H. Brown, S. Rogerson, T. Taylor, M. Tembo, J. Mwenechanya, M. Molyneux, G. Turner, Blood-brain barrier function in cerebral malaria in Malawian children, Am J Trop Med Hyg 64(3-4) (2001) 207-13. [11] K. Dorovini-Zis, K. Schmidt, H. Huynh, W. Fu, R.O. Whitten, D. Milner, S. Kamiza, M. Molyneux, T.E. Taylor, The neuropathology of fatal cerebral malaria in malawian children, The American journal of pathology 178(5) (2011) 2146-58. [12] N.A. Beare, S.P. Harding, T.E. Taylor, S. Lewallen, M.E. Molyneux, Perfusion abnormalities in children with cerebral malaria and malarial retinopathy, J Infect Dis 199(2) (2009) 263-71. [13] M.J. Ponsford, I.M. Medana, P. Prapansilp, T.T. Hien, S.J. Lee, A.M. Dondorp, M.M. Esiri, N.P. Day, N.J. White, G.D. Turner, Sequestration and microvascular congestion are associated with coma in human cerebral malaria, J Infect Dis 205(4) (2012) 663-71. [14] P. Brodersen, O.B. Paulson, T.G. Bolwig, Z.E. Rogon, O.J. Rafaelsen, N.A. Lassen, Cerebral hyperemia in electrically induced epileptic seizures, Arch Neurol 28(5) (1973) 334-8. [15] I. Prohovnik, S.G. Pavlakis, S. Piomelli, J. Bello, J.P. Mohr, S. Hilal, D.C. De Vivo, Cerebral hyperemia, stroke, and transfusion in sickle cell disease, Neurology 39(3) (1989) 344-8. [16] W.S. Bartynski, Posterior reversible encephalopathy syndrome, part 1: fundamental imaging and clinical features, AJNR Am J Neuroradiol 29(6) (2008) 1036-42. [17] E.M. Haacke, Y. Xu, Y.C. Cheng, J.R. Reichenbach, Susceptibility weighted imaging (SWI), Magn Reson Med 52(3) (2004) 612-8. [18] S. Hackett, J. Hamzah, T.M. Davis, T.G. St Pierre, Magnetic susceptibility of iron in malaria-infected red blood cells, Biochim Biophys Acta 1792(2) (2009) 93-9. [19] T. Bosemani, S.I. Verschuuren, A. Poretti, T.A. Huisman, Pitfalls in Susceptibility-Weighted Imaging of the Pediatric Brain, J Neuroimaging (2013). [20] N.A. Beare, T.E. Taylor, S.P. Harding, S. Lewallen, M.E. Molyneux, Malarial retinopathy: a newly established diagnostic sign in severe malaria, Am J Trop Med Hyg 75(5) (2006) 790-7. [21] M.E. Molyneux, T.E. Taylor, J.J. Wirima, A. Borgstein, Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children, Q J Med 71(265) (1989) 441-59. [22] Siemens, MRI Protocols 2010. http://www.healthcare.siemens.com/magnetic-resonance-imaging/magnetom-world/clinical-corner/protocols. [23] M.J. Potchen, S.D. Kampondeni, K. Ibrahim, J. Bonner, K.B. Sey

Sunday, October 13, 2019

Analysis of A Passage to India by E. M. Forster :: passage india forster essays papers

Analysis of A Passage to India by Forster Forster's novel A Passage to India portrays a colonial India under British rule, before its liberation. For convenience's sake, Western civilization has created an Other as counterpart to itself, and a set of characteristics to go with it. An "us versus them" attitude is exemplified in Forster's representation of The Other. Separation of the British and the Indian exists along cultural lines, specifically religious/spiritual differences. Savage or ungodly cultures were to be assimilated into or at the least governed by Christians, and converted. The separation between the English and the Indian occurs when the Christian assumes the Indians are an ungodly people, in need of spiritual salvation, a race below their own, and entirely unlike them. This was demonstrated historically by the dominance of supposedly inferior races by the Christians (English). Forster's Indians have a seemingly rugged outward appearance. They are a godless people insomuchas they do not believe in the Christian GOD, even though there are two religions, Hinduism and Muslimism, which thrive in India. This division of India's religions, as opposed to England's presumably unifying religion, separates England from India even moreso. Because the Indians do not believe in the Christian GOD, they are unrecognized as spiritual. Religion shapes, if not embodies characterization. The British are British because of their religion, i.e. Ronny Heaslop is who he is because he is a white Christian British male. How he is outwardly polished is a construct of his Christian upbringing. Ronny "approved of religion as long as it endorsed the National Anthem [of England]." (p. 65) His purpose, as was the purpose of English colonialists, was constructed by his Christian beliefs. If Ronny were not English (and for this paper's purposes, English is specifically and continually linked with Christianity) he would not exist as a character. He is almost a caricature of what is English, and is represented wholly by t he standards and beliefs of that culture. In contrast, Aziz would not exists if he were not Indian, representing wholly the standards and beliefs of that culture. Forster implies that the division, the Other, is what makes an individual who they are. Spirituality is integral to that existence. The Indian people are further represented in the English's eyes by the description of India itself. The city, presumably a mark of civilization, is a rotting, festering thing that no English colonialist would consider urbane;

Saturday, October 12, 2019

English Media Coursework (Saving Private Ryan) Essay examples -- essay

Analyze the methods used to make the opening battle sequence of ‘Saving Private Ryan’ both shocking and realistic, and say how effective you find it as an introduction to the film Steven Spielberg’s master piece Saving Private Ryan earned itself 5 academy awards, including the best director award in 1998. The all star cast starring Tom Hanks, Matt Damon, Tom Sizemore and Edward Burns brings to life the horror of war. Seen through the eyes of a squad of American soldiers, the story begins with World War 2’s historic D-Day invasion, then moves beyond the beach as the men embark on a dangerous special mission. Captain John Miller (Tom Hanks) must take his men behind enemy lines to find Private James Ryan, whose three brothers have been killed in combat. Faced with impossible odds, the men question their orders. Why are eight men risking their lives to save just one? Surrounded by the brutal realities of war, each man searches for his own answer-and the strength to triumph over an uncertain future with honor, decency and courage. Saving Private Ryan earned its awards for bringing back the realism of World War 2 and for portraying what the shocking chances of survival were at the historic battle of Omaha beach on D-Day in June 1944. Omaha beach was only one of the invasion sites of the American, British and Canadian coalition forces. The special reason why Steven Spielberg chose to direct his movie with Omaha beach as its backdrop was due to the fact that out of all the other landing sites, Omaha beach was the bloodiest battle field and it took 15,000 lives of young American soldiers to capture the beach. In the past, war genre films meant hardcore action and a hero waging a one man war against an army, a typical movie would be Rambo 3. Although it is based on a true story, it did not take one American to battle the whole Russian army with a bow and arrow. Saving Private Ryan brings back to life the real heroes that fought in a war, men who were willing to give up their lives just to make a difference, now tha t ultimate sacrifice is what true heroism is. In a way Saving Private Ryan was finally able to create a difference between action genre films like Rambo 3 and war genre films like Black Hawk Down, and define completely new conventions of war genre films. The realism of the movie is what gave the movie its academy awards. A few explosions cannot bring back ... ...n the beach. Hundreds of bodies lay dead, the music although creates a peaceful effect, the first reaction of a sentimental audience would be tears dripping out of their eye’s. The final shot of the scene is the close up on Peter Ryan laying dead on the beach with a bloody tide rushing in. The ending scene was probably the most effective scene of all because it immediately shows the reality and chaos war brings to mankind and what kind of courage it takes people to rise up against it. Overall I think Steven Spielberg has created a masterpiece in re-creating D-Day. Not only that, the way the whole battle sequence followed and linked each other was remarkable. I mean to say the graveyard, the old veteran crying, the music, really prepared me to expect the next scene to be a battle. But I did not know it was going to be that chaotic and brutal that it literally shocked and surprised me. The accuracy and the, idea of hand held cameras really involved me with the movie and I think that’s what I enjoyed the most, the realism of the movie convinced me that, that is how D-Day happened. Saving Private Ryan was definitely worth watching, it has taken the war film genre to a whole new level.

Friday, October 11, 2019

Identifying and defining problems Essay

Leaders are at the forefront of every organization. They are looked upon by their subordinates in initiating the plans and goals of the organization. In essence, leaders are the guiding light of every organization whenever the latter is experiencing financial and economic woes, turmoil within the organization or disruption in the organization’s work processes. A leader has the power to lift an organization out from the ashes of ruins and into the world of success. But with great power comes great responsibility, hence a leader should have, within him, the element of skill in identifying and defining problems. Whenever an organization, say a company or a corporation, loses its edge in competing in the market wherein it is situated, there is a need for it to innovate and change. Therefore, it is the leader’s duty to instill discipline among the employees, so as to push the whole organization into motion. Although â€Å"it’s difficult to put together a group with enough power to guide the effort or to convince key individuals to spend the time necessary to create and communicate a change vision†, (Kotter, p.36) a leader should have a sense of empathy with the organization’s employees, so as to let him be aware of what the whole organization is feeling about the whole effort of innovating and changing the organization. For problems to be identified and defined there is a need for the cooperation of both the managerial leaders and the rank and file employees. In undertaking a change within an organization, people often â€Å"underestimate the enormity of the task; the work requires great cooperation, initiative, and willingness to make sacrifices from many people. † (Kotter, p. 35) Empathy comes into play here. When the people within the organization know that there leader is to be trusted, they would not hesitate to cooperate in the leader’s efforts. Innovation and change will come eventually. The absence of a major visible crisis, low overall performance standards or a lack of sufficient performance feedback contribute to complacency which, in turn, contributes to laxity in doing the work processes below quality standards. Leaders should be adept at noticing or recognizing these sources of complacency so as to remove any hindrance to an organization’s effort to innovate and change. Add to this, as requirement for a leader, the skill of good listening; for through this, misinformation within the organization would be greatly decreased. It is said that opportunity is problem turned inside out; hence organizational problems often open many windows for innovation and change. The first step in managerial problem solving is problem and opportunity identification. Tushman and O’Reilly (2002, p. 40) said that just as physicians first focus on their patients presenting symptoms, managers must identify their organization’s critical problems. This done, they can then diagnose the causes of these problems and, in turn, take action to address them—while avoiding unexpected side effects. Similarly, once opportunities are identified, managers can analyze those aspects of the current organization that will get in the way of achieving the unit’s aspirations. With the authors’ idea in mind, a leader should know the actual assessment of the organization so that he can properly implement the right strategy to a particular unit in an organization. In doing this, a leader or â€Å"manager (and his or her team) needs to be clear about the strategy, objectives and vision of the unit. Such clarity is the bedrock of managing innovation and change. Only when strategy, objectives, and vision are defined can managers move on to an honest appraisal of the current performance of their organization. † (Tushman & O’Reilly, p. 41) After the mission and goals have been set and are clear in the minds of the unit members within the organization, efforts should be made in determining how the proposed strategies will fare considering the current performance of the organization. This will provide a situation wherein the management can gauge whether the mission and goals of the organization are realistic or not. As Tushman and O’Reilly have stated, organizational performance gaps are the differences between desired and real performance. These performance gaps can be termed as opportunity gaps. When we arrive at knowing these gaps, we would really be able to clearly formulate a clear and definite strategy to use in a particular situation. But strategies won’t materialize on their own; it needs painstaking efforts to be able to arrive at these strategies. What can a leader do about this? A good leader knows that he cannot steer the whole organization, especially if it is a big one, towards its goals on his own. He needs the help of all his subordinates. It is needed for the leader to encourage the management and the rank and file employees to join him in formulating and implementing these strategies for innovation and change to be realized. It is a fact that â€Å"creative thinkers tap into their imaginations by combining and recombining ideas or concepts to make new connections. Creative thinking is really about discovering new connections through the use of the imagination, diverse stimuli, and ‘creative-connections power tools’. † (Dundon, p. 42) In addition to these approaches for identifying and defining problems and opportunities for innovation and change in an organization, Dundon stated (2002, p. 64) that a preferred method for idea generation is having an â€Å"Innovation Group† which, because of its comprehensiveness and rigorous design, goes beyond the more common brainstorming method. This allows discussing and formulating ideas at a higher level within the group. Once these approaches have been taken, what a leader should do now is to carefully evaluate how the organization reacts to these implemented strategies so as for him to make necessary corrections when the need arises. ABSTRACT There are many approaches to identify and define problems that confront a particular organization. These problems would not be addressed and be made visible without the guidance or skill of a good leader. Hence, it is needed that a leader is knowledgeable of the processes of an organization, empathic and, best of all, a great innovator himself who believes in positive results that innovation and change bring to an organization. Sources: 1) Dundon, Elaine (2002). The Seeds of Innovation. New York, American Management Association 2) Kotter, John P. (1996). Leading Change. Massachusetts, Harvard Business School Press 3) Tushman, Michael L. , & O’Reilly, Charles A. (2002). Winning Through Innovation. Massachusetts, Harvard Business School Press.

Thursday, October 10, 2019

Marketing Story

Bad reputation and feedback trot some experienced guest from other companies may affect In the capacity of registering of the potential guest strength: * Unique, unpopular, perspective type of tour especially In Vietnam Vietnam Is an agricultural country which is new and unfamiliar with the foreigners. This tour is unlike many other tours, It give the tourists some realistic views and have new Interesting experiences which they can have never been before about the local peoples life. New services, activities held up such as life by taking part in some agricultural activities, cooking traditional foods, visiting the carat village and doing charityÃ'›_ Tourists can also taste, enjoy and bring the products they made as souvenirs. Which are much more memorable and remarkable than normal gifts. Weakness: * New Corcoran, low reputation, small scale due to Limited capital As a new comer, the company hasn't got much reputation so It's not easy to attract many guests, The limited capital u rged the company to balance carefully expenditures.At first, the scale of the tour may not big, the Limited number of a group Is about 1 – 10 people to get experiences, fix the problems and complete the tour plan. * Place: far from central area The organic tour requires a quite large natural areas, which can provides the tourists to only the space for the activities but also the finest and most relaxing delusion_ The location is in the curbs of Hanoi, far from the urban area where has more modern facilities: hospital, shopping mall, recreation center†¦. The tour may takes much time to travel among tourist destinations. The distance between the place to the destination such as the nearby craft village may take more time to arrive. * Inquire investment on providing facilities: The tour Corcoran can be together with the host providing or upgrading the facility to the houses in order to bring to the guest he most convenient living condition. It's up to the contract between t wo sides: The host or the company pays for the expense. This can cost the company a lot.Upturning: plans and activities according to the region culture. Many places have some advantages to develop this type of tour is in the Red river delta, Mekong river delta, the central of Vietnam†¦ * Attract guests for new services, new programs in the tour: recording videos, playing games, volunteer activities, visiting craft villages and earning how to make the traditional product, trekking, biking, riding around to enjoy the scenes, having a tour around the city†¦ Threatens: * Facility condition This is one of the most required in the tour.Tourists want to be provided basic facilities to meet their basic needs, to entertain, to communicate,†¦ The cleanses, convenience, comparability, privacy,†¦ Are the standard elements. The provider/host have to make sure that the facility is always ready to serve the guest in the best condition. However, the company can't always control this thing, it depends on how he host work. * The host's attitude and action directly influence in the quality and guests' perception and satisfaction.Local people is a very important element in deciding the tour is success or not. They live, communicate with the tourists so they affect directly on the tour quality. If the host has a positive and enthusiastic attitude, try to show and help the guests, this could lead to a good result and make the guest satisfied. In contrast, if the guest is served with a bad attitude by the host, this can influence to the company's reputation, which is absolutely not goodÃ'› especially for a new company. Bad reputation and feedback from some experienced guests from other companies may affect in the capacity of registering of potential tourists. Nowadays, people often pay more attention and read reviews about the place/ service/product they are willing to spend money on. If there are companies which also operate this type of tour and haves some ne gative comments on it, this may lead to the consequence is that some others tourists don't want to use the service, and change the plan.

Wednesday, October 9, 2019

Big Mountain High School Case Study Analysis Education Essay

In this instance survey analysis, I will give a brief sum-up of the instance and the jobs I found along with particulars. I will besides supply recommendations for the territory and school leading that will turn to the awaited barriers to alter. I will establish my recommendations on the needed readings for this class every bit good as other theoreticians and their research applicable to the instance survey. Big Mountain High School serves over 1450 pupils in grades 10-12. Large Mountain is the lone high school in the county, and besides the largest high school in the province. Its geographical location is known for its wilderness and beauty. Because of its location it is mostly a rural territory where many of the attending pupils commute more than 30 stat mis every twenty-four hours to have day-to-day direction. The population of the school ranges from diverse socio-economic backgrounds. As evidenced in the instance, 40 % of the pupils will travel on to go toing 4-year colleges, while 20 % of the pupils attend 2-year colleges. For pupils that are non college edge, as an excess educational option, the territory provides them with a vocational plan ( Smith & A ; Louis, Winter 1999 ) . The Superintendent of the territory is Mr. Bob Carpenter a indigen of the territory. He has been the overseer for four old ages and he is described as being magnetic, a individual who makes determinations and gets things done. He is extremely respected amongst the instructors and staff because he meets straight with the instructors and listens to what they have to state. Mr. Carpenter is besides described as utilizing a bottom-up leading manner doctrine. The chief Mr. Vogel has held the place for 15 old ages. He is known as being a dedicated manager, candid and carnival to his staff. Mr. Vogel besides adopted a bottom-up leading manner doctrine. Some nevertheless, see him to be â€Å" crusty and impersonal † and even unapproachable. He makes hiring determinations, nominates the section chairs, normally communicates with instructors in short staff meetings, and maintains that disposal has full authorization over the processs and policies in the school. The sections at Big Mountain high school were given entire authorization and liberty as how they distribute the instruction assignments, how course of study and direction is designed and they besides make the determinations on budget allotments. Meetings between the principal and section caputs are non regular events, they normally meet one time every three hebdomads and the meetings are normally really short. Finally, there are the instructors. The territory ranks the highest paid among other territories in the province, supplying the territory with a big pool of extremely qualified appliers. Teachers at Big Mountain command how they teach, have small or no treatments over learning methods, the type of direction, and have small or no input in the determination doing procedure that takes topographic point in the school. Faculty is divided and with really small interdisciplinary engagement. There are several leading issues present in the instance. The major issues revolve around the ability of the leading to expeditiously take the school during a much needed alteration. In the instance of the mandated course of study alteration as required by the province, the treatments of the new course of study raised personal and pedagogical differences amongst the module. If the end of the leading is to further growing and alter the way in which the school is traveling, it would be wise for the leading to take a human resource frame attack as discussed in Bolman & A ; Deal, where under the human resource frame, leaders provide and foster equal engagement in the determination devising ( Bolman & A ; Deal, 2008 ) . At Big Mountain, the caputs of section have a significant sum of influence and authorization, and are perceived by the module as decision makers and determination shapers. These differences in power have led to a deficiency of interdisciplinary engagement between section caputs and module members where Hargreaves & A ; Fink refer to as, traditional power blocks ( Hargreaves & A ; Fink, April 2004 ) . This deficiency of interdisciplinary engagement and the misinterpretation of a collaborative leading, as become a top-down hierarchy leading, instead than a sensed bottom-up leading as expressed by the chief Mr. Vogel. It is obvious that the principal in this school will non be developing meaningful relationships with the staff. His neglect for the sentiments of the instructors during his short module meetings, along with his important leading manner resemble what Fullan ( 2001 ) describes as coercive and bossy leading. As the freshly appointed caput for the Language Arts Department, Mr. Chester non merely appointed to the commission merely those who agree with him, he besides restricted the engagement from the instructors that will be implementing the course of study. By making so, he derailed Bolman & A ; Deal ‘s model attack, and the construct of the structural frame where the attempts of groups and persons are coordinated, and besides the human resource frame, where affecting others gives them a sense of belonging and ownership ( Bolman & A ; Deal, 2008 ) . Even though ab initio the principal shared the determination devising with the commission, he rapidly reversed that determination and decided to do the determinations himself. However, subsequently he decided to name Chester to take the new alterations commission to implement the new course of study. One once more his rushed determination was made without the engagement and the input from the instructors, go forthing it small room to win and showing the deficiency of communicating and alliance edifice, necessary when turn toing alteration ( Kanter, Summer 1999 ) . As the overseer, Bob Carpenter was non of much aid to the principal in set uping and developing a successful civilization of committed members within the organisation. Although important and magnetic, his strong interaction accomplishments, the ability to construct relationships while run intoing with instructors and listening to their concerns when the principal was non supportive, have earned him the regard of the instructors, minimising the authorization of the principal. As the overseer, Bob failed as a function theoretical account, and a wise man to the principal. He came across as holding his ain political docket, showing the deficiency of his leading qualities. Qualities required when constructing a successful organisation. Recommendations for ImprovementInspiring leaders have the ability to turn schools about. On the other manus mediocre leaders can alter the civilization of a school and hinder the patterned advance of successful enterprises that may be ongoing within an organisation driven by its members. â€Å" A civilization of alteration consists of great celerity and nonlinearity, on one manus and every bit great potency for originative discoveries on the other. The paradox is that transmutation would non be possible without attach toing muss † ( Fullan, 2001, p. 31 ) . It is obvious that muss is in the hereafter of Big Mountain. Changes are inevitable, and a complete restructuring of the school is recommended. From the overseer, to principal, to section leaders, and to instructors, all fail to develop a collaborative and cohesive work environment. In the instance, the prostration was initiated from the top-down where is lacked sustainable leading. Hargreaves ( 2009 ) describes five obstructions that impede effectual leading and should be addressed in the restructuring procedure of Big Mountain. The obstructions impede the successful execution of the restructuring when sequence is ill planned, sequence passages are severely managed, sequence is frequently on the incorrect frequence, sequence planning fails to see the emotional facets, and in conclusion sequence is non treated as a systemic job. Sequence in leading is an of import facet when reconstituting an organisation and it is frequently overlooked, weakening the long term alterations for a successful turn-around. Large Mountain could profit of an increased stableness in leading. It was evident that neither the overseer nor the principal were wholly dedicated to the school and its vision. The overseer and the principal could hold been more proactive in edifice and set uping a common vision for the school. Constructing a systemic leading is another of import facet that should be taken into consideration. The overseer should work on developing unfastened lines of communicating with other successful schools in the territory, and develop partnerships with the other schools where information is shared, and thoughts are exchanged leting schools to assist each other and ultimately addition accomplishment. Another recommendation involves the development of a distributed leading and the creative activity of managers for the new leading. Bolman & A ; Deal ( 2008 ) depict the human resource frame, where the overseer and the principal would put more accent on constructing personal relationships, and the s chool would profit from the constitution of an unfastened and true bottom-up leading manner doctrine. Because more and more disposal is comprised of first-time leaders, giving support to new leaders will relieve the emotional emphasis associated with the place. Supplying good back uping managers will assist the new leaders with the troubles that come with the new administrative function. A concluding option is to maintain the position quo of the school. However, without alterations in leading, the instability that exists amongst the staff will stay and will go on to decline. Leadership stableness can be improved by leading sequence, and this may be accomplished by administering successful leaders across schools in the territory and developing a support web that will help overseers, principals and instructors throughout the territory. â€Å" Successful sequence is about turning and linking leading throughout a system, non merely happening the right tantrum for single leaders. † And â€Å" Permanent betterment seldom exists without leading stableness or successful sequence. Effective sequence is a strategic challenge but non an unsurmountable 1 † ( Hargreaves & A ; Fink, April 2004 ) . MentionsBolman, L. G. , & A ; Deal, T. E. ( 2008 ) .Reframing organisations. San Francisco: Jossey-Bass. Fullan, M. ( 2001 ) .Leading in a civilization of alteration. San Francisco: Jossey-Bass. Hargreaves, A. ( 2009 ) . Leadership Succession and Sustainable Improvement.School Administrator, 66 ( 11 ) , 10-15. Retrieved from ERIC database. Hargreaves, A. , & A ; Fink, D. ( April 2004 ) . The Seven Principles of Sustainable Leadership.Educational Leadership, 61 ( 7 ) , 8-13. Kanter, M. ( Summer 1999 ) . The Enduring Skill of Change Leaders.Leader to Leader Journal( 13 ) , 15-22. Smith, B. , & A ; Louis, L. ( Winter 1999 ) . Case 2: Changes at Big Mountain High School [ Abstract ] .Journal of Cases in Educational LeadershiP, 2 ( 1 ) , 1-2.